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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b2346b7e429dace933e3da5980256a71a279370086505785cb3ad88a36b6c16' 
  AND token = 'GWApuSm8eNiOwr22+T2Iwlg9I/gy8HvXZ6hYUnjze78=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}