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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '460e606758d4c6dcf4fc31d79c2c78ada884f6f6be5b7c7eb8439165338368e0' 
  AND token = 'n8Y59fnSYIQ6tjc84Je4Gdf4vRNUovidWHmt3YBI1TA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}