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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2704e7d8f4f09fffe3fa61d6f1d9a21c442412b670e5f0e44c7074be4e15122' 
  AND token = 'ZpZlN+eV/LvAcvPXm2k4QhTKhpZ4n9jrPoUuO5NMGog=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}