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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d1a3703370a04197b21e3bdca48f54d55b88fa68ee2da21e876d32af02a5001' 
  AND token = 'K3owpCIfNJuXPJiUbbg1+JRVncdTCJVKfHTrb7DbOqE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}