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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a15b295df08237dc260f9de8250c4b43486988d40fda24ca5c708b70aa580891' 
  AND token = 'e1wSBBzMQZiaEVaaLKT7ITJwWS2XNfCfnj5iP8DnWz0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}