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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '719126d77e5674174f3095ff9a7c4bf0f19e36b94e4ca9ba04f9da5f97a15641' 
  AND token = 'Ro2L/6AckF2DSA1pALTCsQ+yi7sz0HPEqGe4thwsiT0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}