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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49cf9840026cbb737186ff9e27836ea2396cb2e9e6315a59c79485a5556c5d07' 
  AND token = 'Y7+zW7WDQMMXiqdpZOzTd9SwUrGPrwos0LEo4f8IIo4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}