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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de58b18f21467daf3eed99f29d15deed68421907fabdecce65eb9a4f3c593fd4' 
  AND token = 'fECBaee/VjTYb0UXm70qyKBSQppdqIAdk1JzVB6JATE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}