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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2406b55877469b50e412377851b049877846620e7c34fda04a21318e9077c37c' 
  AND token = '+XQu5crm/GN/69WSqEZAyeLl0BHMhtNoRV0Thybpka8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}