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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7356d4a65a9a69c7cf400552164710b80efff910be2c7300d2c8ee347ec62def' 
  AND token = '3P6drJ94saptPf3LVCkbGe6hJfowlWOUhozkufy6acQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}