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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de45b8e2523094fd20b7307e3e674cd287a2900367616ced900b8db770bb5b9b' 
  AND token = 'XGj8zV28NGiiblVBhTRhqcKRtVbTUcQvRPhR1qodfv4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}