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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a88c1049f2caaee6c16b4d84b9302864ce17d5783b095f2116c8c101faee1d5' 
  AND token = 'HFKQOLO2C7BGVs+281cE9YClyP7O7qsxRoxTqLHFZdc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}