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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8e4e58f42472142e81efd4bd9f549418708c505ce267cfe8274b4e77e80b151' 
  AND token = 'DZ34iw2k+4FSG9CfemXqHGY8SbWcJRNkbbaaB5PZ1Qs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}