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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7099ffb0cfc25e3f8a2e9f11647158452f0c780a23fa2441e1fe507f34dcd251' 
  AND token = 'Lnhhuin5c+s8SuZtzAvu61YeJHJMEWZEU9PAtxB1LTM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}