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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '492423b802671beaf515300892759908de8373abe3ee41d0d5b161aa2d13dad3' 
  AND token = '+b+MyMQYA00g8XhmoZg1wdnQ1B9fXqcdPOQhaUQYDPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}