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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '125447d0f9cd07b1f55ed2dafe8c26490fe78c030a10a5dfab152803267cc07b' 
  AND token = 'UQMj6wa9h1WYDq8MK7VSEjoDnrKLZ9MBZ4+dYcBYK2U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}