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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e95064bbd2d9cae776c3bbbe01cc56439916a9e3ddb00839b582003383fde4b' 
  AND token = '4/4dkNxcPjl+O+UsrSBwVtbYYjRfkKiUDj5au/TSSWA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}