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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50ab8c8b6a5d812bba556e50fa018d0f2022161d7a0afe1bb4e8cb549bc3e686' 
  AND token = 'gwyhtIQ6nDP7qTGgGsqxKkNW7KrdOfhWQ23VubqNwwU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}