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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59c9f2c6a98b5c4b167e61a596623c98c83461b60fbea6758aa7a69627cebd1a' 
  AND token = 'tR0uJAuwlVI+eTBMQ2FqSldJxC5N+BbzhXf6RJaiUYY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}