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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2448f4b25bc7d45a19ef7fcf6ab2a1874f11a2e3e9da4dde27e1b0d5a9348263' 
  AND token = 'slJc6McgafjhV1m8cgq718++shDIMIVa+YGXvYaVcik=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}