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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5246951d263e126c0b9c9426873cd9e331aee5d87d0a69e038509c795d3b859' 
  AND token = 'd9YlCxexYxpp9SE3sj98Eo3rItUwNj93Ato/c6AE2CQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}