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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4e80db2d46a64b3e7ffcfde80bdfe1f229a48101c1922489e1cde4e241be586' 
  AND token = 'd5bZyaBVOP14OsOOh9fg+dE31HT4AKsqf3+EpEIRtoY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}