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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '13450563216f11b71ef3019cedf4a21c2e31120fa4ce4491d3f3bbc763ea0280' 
  AND token = 'DBJZ9Hgjhmk7tbDXbHhBQ6woxx0zKj4xqsOgxSy20R0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}