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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22acf044aa75712311fc24477639540dbe00863f84afeb1666e76cfb5ac7ae56' 
  AND token = 'unzRmr43OBo6veCVvN3Da+pXzCaXK4MAiK7fTDXY+4U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}