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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41e06c25741a81df39fe7cb8e7d83d63e07566f62e11e76f9b58ccdbcc14f726' 
  AND token = 'UEGfenErYU772UXVBYCTMvckqHGTmgkPGt2m4xdO6JY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}