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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21d7f99b9bbf9e59120df64b2050d4da4704722ff78998afb4c8d5d6c4533147' 
  AND token = 'yq2JZ5hDWwTSA2hdL182Uia6eiH6Ba2CLLZDycCH+EU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}