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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e6080f78f7cff749701d2632b11f3dc29be3a46c4f6561de5acf09a9b014e54' 
  AND token = 'htMBMjh3rMa628+KShtCUi5v2QEJfyQT/8qXnSxxB7g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}