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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c29f78138a3d19221baa7b8c57aca35280b234409e20b6306b8f3eb770ca5433' 
  AND token = 'nMJR/ziT46TuB0rXMr0cSaiH4vjm9qF3wsvhVGECAB0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}