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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f49ae49068927c93fa927e3a7a4c18619f2107798580181741d9e67a6f58171' 
  AND token = 'vF4+hVtYNFHJJG0sr+mNt/phItnaexjFUITR7mZlimE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}