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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ce648dfbcedbb7d5822a0411ae07dd276121bea3d3a29f536f3494aa3409332' 
  AND token = '3EcBVFBfCaH1opoqrhSRK4hsCifdLPiT1saLx6fkE9c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}