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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22157d7b901b5a103e9461b4ca4fb767ad4ca27956117caed7e99da820dc8a1d' 
  AND token = 'LbTJsg/KyE6qJHMGx6bYG8dJciZLMjKL0UbfGLk+E+o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}