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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28e7ca2833c57a2207fe4dbc5e54d1c34481dba55742e635451434247c488ceb' 
  AND token = 'U0POhUi8CzV1bUnd0EWtQOUi3tSHMC0nXH5jdYB0gYI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}