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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '727a77a6992a7313030a8ac0b1dd4b50459bc7d33eccdfdca1543a8c78b06820' 
  AND token = 'rYOSMzIOqDBS8hbkmu3s8tq+qp/crzBEmnDAF+sijMA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}