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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6dad73c63c91f9bc44d862847b02f47664282a01abbdcc0bec9fcaf12b7a6c1a' 
  AND token = 'L4e3VVLEiPq8v2QZMXIft3fyqLlcKDnlWHOWdFpqcm0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}