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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50fe51865dcce7d6af4b5b38f16af3bec36d0dc4e763bb2ce77409d1c0478de0' 
  AND token = 'R3lKFmBRM8VofpToGYDdI6l52eKTm9cAD40WI+WOLSA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}