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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '381ab3e5975b42a17e0c9c09cc373b44e458be61deef3c5408bf947297a2068a' 
  AND token = 'TJXeEHuZ/X8RHsfq63P1lNl53rhlOFoBe+q5mNUPzrc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}