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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '200bab01720b442748120a3a10e33524421b1d059ab3aa36ee50698a0ad60286' 
  AND token = 'S+vMbMvmIUuwGqsT17w//LdnsWYo/m48GBKC6rbRPQI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}