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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53576ea11b78ccb4c67e00d444a63883e46ac5210f2ac03a0ed836493b5d2609' 
  AND token = 'RWCUO6h5My0ZEzCKQiRTlzRwsijKazONS20kwAI0Ohw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}