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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ccd5805fb564784f23461e2edb7c316414f2832a2fefa77af64ac593cd4f14' 
  AND token = '5vqcHfsCUloK+lGbAfj8zVO3yqYIsv4rUG2kx8XWeTU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}