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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78d93edf1e1cdd71fbf04acefce3e97ae1579f1b266896255d64cbfdd83cc516' 
  AND token = 'K1C96VrgB0Re38tETXzDvhGb8gYB8lVu10nkMnxfiNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}