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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a649f790b689ee22fb76125b5907b36076998bdb3a522764a50353bc3703a578' 
  AND token = 'E2TXtpJgT/9dQRtVdJhZ2ZX7KPnMXBKOQChL8cJIQ9s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}