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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4d0b6a9a7963d88abf84d7e804737891673510b6eba2dc3b4e72bc2df31bb43' 
  AND token = 'IKiHQIfQyC+k6zoRZHNEnEoI0GOS7R53XRSS7SRPKpg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}