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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '642f69d68438e76178a156774473a8dc0cf219149f35d0e07bc3252a8fa51278' 
  AND token = '9vTgL16tMVykaCDARIR2KNyai1iazuxrU1w+V2V/wAA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}