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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5d922fd6661cde8801ad60ebe45cf8d0067395b62271c36e6c264b8633d2518' 
  AND token = 'k4DEc5iRjD7czYuadS9nL0/p4wwYxBZRJ2MUlnl7t4Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}