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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e59d3a3995e0335e834cca6f742a863f7ad4f4a311c81b19d837e67b78bbcf84' 
  AND token = 'zo0m6aJVeQDtddlQ9mh+T4sBF4HH5QLbuxtjHOsllRA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}