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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '314b35225a0372b42a01812deb7d331e2d18eacfa63fb60ae196b809d21348ff' 
  AND token = '4hfs5kaiS2UaxR+DKIC7VWIPyXlsqpJnxKAA7AoHRrA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}