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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e827f3e4e0eef019d00edef90951ac1608e7c6ae046504c7e298f11c102b872' 
  AND token = 'cQC+DPLFZdjquIR5MeRirg8auTwczkiGFugEKKR6yZk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}