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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e143345257dd33556f2d057f77dfb66a38ccc8896b30a354ac15da4dd96ad80' 
  AND token = 'ESCEgS+v+o3WQIF5TZYhfUv6aiZB4DS1abUQ89q6nL0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}