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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28b9841175e44e2fb8769f22df639b565f45203221fe03efee0ab73092a5eb1c' 
  AND token = 'OSQkaG5AeFp6Tax4t8Sn1ogtyfzuXcfMsgnkGTzDCPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}