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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ad5a51448302736207ea73015e91a8007393e4e9494006c4f0ed45f1c8cede7' 
  AND token = 'M6FbT+kFofgKPVQQMk5PJ9m8R0A0hS3HFiY/pS3Fl3E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}